Diego Simeone may have to rethink on how to line up his charges when Atletico Madrid face Man United in the Champions League

The defending La Liga champions are likely to miss the services of several players for the United visit including captain Koke.


Koke is understood to have picked an injury during Atletico's weekend win over Osasuna in the La Liga

Other players believed to be major doubts for the Man United clash include winger Thomas Lemar and Griezmann .


According to reports, Simeone is likely to miss as many as seven key players for the encounter, including skipper Koke.